Image of Fibrinolytic Proteins of normal Pregnancy and Pre-Eclamptic Patients in North West Nigeria

Reproductive Health and Wellness

Fibrinolytic Proteins of normal Pregnancy and Pre-Eclamptic Patients in North West Nigeria

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Background: The hypercoagulability of pregnancy is exaggerated in pre-eclamptic state because of endothelial activation
with resultant production of some endothelial derived proteins that are said to be inhibitors of fibrinolysis. This study compares
these proteins like tPA, PAI-1 and D-dimers in normal pregnant women and the pre-eclamptic women.
Methodology: This was a comparative cross-sectional study. Eighty-five pre-eclamptic women were recruited as subjects and
eighty five age, trimester and parity matched normotensive pregnant women as controls. Levels of PT, aPTT, tPA, PAI-1,
D-dimer protein were determined in blood samples of subjects and controls. Urinalysis was performed with dipstick method
on their urine samples. Data generated was analysed using the IBM®SPSS 20.0 (2011) soft ware packages and the level
of significance was a p-value

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English
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Subject(s)
Pregnancy
Fibrinolysis
Pre-eclampsia.
North West Nigeria
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Article
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