HIV & AIDS

Human Immunodeficiency Virus Type 1 Drug Resistance in a Subset of Mothers and their Infants receiving Antiretroviral Treatment in Ouagadougou, Burkina Faso

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The emergence of HIV-1 drug resistance
(HIVDR) is a public health problem that
affects women and children. Local data of
HIVDR is critical to improving their care
and treatment. So, we investigated HIVDR
in mothers and infants receiving
antiretroviral therapy (ART) at Saint Camille
Hospital of Ouagadougou, Burkina Faso.
This study included 50 mothers and 50
infants on ART. CD4 and HIV-1 viral load
were determined using FACSCount and
Abbott m2000rt respectively. HIVDR was
determined in patients with virologic failure
using ViroSeq HIV-1 Genotyping System kit
on the 3130 Genetic Analyzer. The median
age was 37.28 years in mothers and 1.58 year
in infants. Sequencing of samples showed
subtypes CRF02_AG (55.56%), CRF06_cpx
(33.33%) and G (11.11%). M184V was the
most frequent and was associated with highlevel
resistance to 3TC, FTC, and ABC.
Other mutations such as T215F/Y, D67N/E,
K70R, and K219Q were associated with
intermediate resistance to TDF, AZT, and
3TC. No mutation to LPV/r was detected
among mothers and infants. The findings of
HIVDR in some mothers and infants suggested
the change of treatment for these persons.

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Publication Information

: ., 2018

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Language

English

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Subject(s)

human immune-deficiency virus
Type 1
Drug Resistance
Antiretroviral Treatment
HIV-1 drug
Antiretroviral Therapy
Ouagadougou
Genotyping system

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Article

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